Manchester City and Manchester United go head-to-head at the Etihad Stadium this afternoon in the 188th meeting between the North-West city rivals.
The Premier League champions and United return to English top-flight action after the final international break before the 2022 FIFA World Cup in Qatar.
Both sides sustained injury blows during the break in central defence, with both John Stones and Harry Maguire ruled out of today's meeting with problems picked up on England duty.
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Nevertheless, Pep Guardiola will be buoyed by the return of another player in the same position.
Aymeric Laporte is closing in on making his Manchester City return, after working on his rehabilitation and match fitness throughout the summer and early stages of the new season.
The Spain international underwent surgery on his knee at the end of last season.
Pep Guardiola's side will be looking to pick up exactly where they left off prior to the international break.
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A dominant 0-3 away victory over Wolves at Molineux left Manchester City in the perfect state of mind towards the top of the Premier League table.
That day, it was goals across the front-three, as yet another strike from the inevitable Erling Haaland was complimented by efforts of their own from Jack Grealish and Phil Foden.
As Manchester gears up for yet another fierce encounter between the bitter rivals, here is how Pep Guardiola and Erik ten Hag have chosen to line-up their respective sides.
Manchester City
Starting XI: Ederson, Walker, Akanji, Ake, Cancelo, Gundogan (C), De Bruyne, Bernardo, Foden, Haaland, Grealish.
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Substitutes: Ortega Moreno, Carson, Dias, Laporte, Alvarez, Gomez, Mahrez, Palmer, Lewis.
Manchester United
Starting XI: De Gea; Dalot, Varane, Martinez, Malacia; McTominay, Eriksen; Antony, Fernandes, Sancho; Rashford.
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Substitutes: Heaton, Shaw, Lindelof, Fred, Elanga, Pellistri, Casemiro, Martial, Ronaldo.
Kick-Off at the Etihad Stadium is 14:00 BST. Find out how to watch the game LIVE here!
Topics: Manchester City, Manchester United, Premier League, Football, Pep Guardiola, Erik Ten Hag
Freddie Pye