Manchester United and Chelsea are meeting for the first time at Stamford Bridge this season in the Premier League.
The fixture means Erik ten Hag will have now faced all five of the other 'big six' teams in the Premier League once this season, winning three and losing one, against Manchester City.
Manchester United most recently defeated Tottenham Hotspur on Wednesday evening, with Fred and Bruno Fernandes getting the two goals in a 2-0 victory.
Speaking in his press conference ahead of the fixture, Erik ten Hag said: We have a big game to play, so all my focus is on that game, all the focus from the staff is on that game and all the focus from the players is on that game.
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"We have to win that game, and we have to do everything we can, so we need full concentration to prepare for that game and to play our best.”
One major talking point, obviously, is the absence of Cristiano Ronaldo from the squad.
When asked on the situation, Ten Hag said: 'm responsible for the culture and I have to set standards and values, and I have to control them.
"We are in a team and in a team we have standards and values, and we have to control it. So after Rayo Vallecano I said it was not acceptable, but he was not the only one. That was for everyone.
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"So when it's the second time (that Ronaldo has left the stadium early), that will have consequences, and that is what we did. So we miss him tomorrow and that is a miss for us and the squad.
"It's a miss, but I think it's important for the attitude for the mentality for the group, and now we have to focus on Chelsea and that is the most important (thing).”
The line-ups have now been confirmed.
Confirmed line-ups
Manchester United
Starting XI: De Gea, Dalot, Varane, Martinez, Shaw, Casemiro, Eriksen, Fernandes, Sancho, Rashford, Antony.
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Subs: Heaton, Lindelof, Malacia, Fred, McTominay, Pellistri, Iqbal, Elanga, Garnacho.
Chelsea
Starting XI: Arrizabalaga, Azpilicueta, Chalobah, Silva, Cucurella, Chilwell, Loftus-Cheek, Jorginho, Mount, Sterling, Aubameyang.
Subs: Mendy, Chukwuemeka, Gallagher, Kovacic, Zakaria, Havertz, Pulisic, Ziyech, Broja.
Topics: Manchester United, Chelsea, Cristiano Ronaldo, Erik Ten Hag
Dylan Penketh