It's believed the Glazer family would consider selling Manchester United if they received a bid of over $10 billion.
Supporters at Old Trafford have been unhappy with their owners since 2005, staging several protests in the last 18 months.
United haven't won the Premier League since 2013, but the Glazers are adamant they don't want to sell.
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According to the Daily Star, it'll cost a record fee for a sports team for the Americans to part with their most valuable asset.
That would make United the most expensive sports team in the world by quite a distance. NFL side, the Denver Broncos, currently hold that record after being sold to the Walton-Penner family for $4.65 billion earlier this year.
The Glazers' valuation of United is larger than the Dallas Cowboys. The five-time Super Bowl winners' valuation is $8 billion.
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Protests against the Glazer's ownership in August saw Sir Jim Ratcliffe emerge as a potential buyer.
Ineos founder Ratcliffe showed interest in speaking to the Glazers about a purchase during the summer, but nothing came of the discussions.
Ratcliffe, Britain's second-richest man, discussed United during an appearance at an event hosted by the Financial Times on Tuesday.
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He declared: "Manchester United is owned by the Glazer family, whom I have met. I've met Joel and Avram and they are the nicest people I have to say, they are proper gentlemen.
"They don't want to sell it. It's owned by the six children of the father and they don't want to sell it."
The 69-year-old showed interest in Chelsea when they were on the market and owns Ligue 1 outfit OGC Nice.
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He continued: "If it had been for sale in the summer then, yes, we would have probably had a go following on from the Chelsea thing, but we can't sit around hoping that one day Manchester United will become available.
"We have an exciting sporting franchise, but the one thing we don't have is a premier team.
"The most popular sport in the world is football and it is the sport we were brought up with and it's the one most close to us. We really should have an asset in the sporting franchise."
United beat Everton 2-1 in their last game and return to action against Omonia Nicosia in the Europa League on Thursday evening.
Topics: Manchester United, Premier League